Palmitoyl Tripeptide-8 Cosmetic Raw Material Wholesale

How Does Palmitoyl Tripeptide-8 Work Against Skin Aging?

Palmitoyl Tripeptide-8 is a bioactive lipopeptide designed to address inflammaging, neurogenic irritation, and skin sensitivity, which are key drivers of premature aging.

Core Mechanisms of Palmitoyl Tripeptide-8

1. Anti-Inflammatory Action at the Source

Palmitoyl Tripeptide-8 directly targets inflammatory signaling pathways:

• Inhibits key pro-inflammatory cytokines:
  • IL-6
  • IL-8
  • TNF-α
• In vitro studies show up to 30% reduction in inflammatory mediator expression
• In vivo human tests demonstrate:
  • 52% reduction in erythema area within 48 hours
• Suppresses Substance P release, reducing:
  • Vasodilation
  • Edema
  • Burning and stinging sensations

Result: Calmer skin tone, reduced redness, and improved tolerance for sensitive skin.

2. Skin Barrier Reinforcement

Beyond inflammation control, Palmitoyl Tripeptide-8 strengthens both physical and immune barriers:

• Increases filaggrin synthesis by 17.8%
• Promotes β-defensin secretion, enhancing innate skin immunity
• Reinforces stratum corneum cohesion
• Reduces recurrence of sensitivity and irritation

Stronger barrier function and long-term skin resilience.

3. Enhanced Penetration & Targeted Delivery

• Palmitoyl modification significantly increases lipophilicity
• Compatible with liposome encapsulation systems
• Transdermal penetration efficiency reaches 2.3× that of conventional tripeptides
• Enables targeted delivery into the dermal layer

Higher bioavailability and faster onset of visible benefits.

Stability & Safety Profile

Stability

• Stable under:
  • pH 5.0–7.5
  • Room temperature conditions
• Avoid direct combination with:
  • Strong oxidizing agents
  • Strong acids or bases
  • High concentrations of preservatives
    to prevent activity loss.

Safety

• Verified through in vitro and human testing
• Low irritation potential
• Suitable for sensitive and reactive skin
• Non-comedogenic
• Excellent formulation compatibility with most cosmetic ingredients

Core Chemical Profile & Functional Significance

Property Category	Parameter	Technical Significance
Molecular Structure	Palmitoyl-Lys-Val-Lys-NH₂	Palmitoyl group enhances lipophilicity; dual lysine residues strengthen electrostatic interactions
Molecular Weight	555.8 g/mol	Small peptide size improves stratum corneum penetration
Lipophilicity	Log P ≈ 3.2 (calculated)	Palmitoylation significantly enhances epidermal permeability
Stability Range	pH 4.0–8.0	Protonation may affect penetration efficiency in strongly acidic systems
Isoelectric Point (pI)	≈ 10.5	Positively charged at physiological pH, facilitating interaction with negatively charged skin components

Synergistic Formulation Combinations

Collagen & Anti-Aging Enhancement

• Vitamin C
• Copper Peptide (GHK-Cu)
• Palmitoyl Tripeptide-8

Boosts collagen synthesis and improves skin firmness.

Barrier Repair & Skin Resilience

• Ceramide NP
• Cholesterol
• Palmitoyl Tripeptide-8

Restores lipid balance and strengthens the skin barrier.

Anti-Inflammatory & Soothing Systems

• Bisabolol
• Madecassoside
• Palmitoyl Tripeptide-8

Ideal for sensitive, post-procedure, or reactive skin formulations.